Storage:
active substances: 1 tablet contains acetylsalicylic acid 300 mg, paracetamol 100 mg, caffeine 50 mg;
excipients: citric acid, monohydrate; potato starch; lactose monohydrate; povidone; croscarmellose sodium; microcrystalline cellulose; calcium stearate.
Medicinal form. Tablets.
The main physical and chemical properties: tablets with a flat surface with a line and chamfer, white or almost white in color, with a weak specific smell. Marbling and inclusions are allowed on the surface of the tablets.
Pharmacotherapeutic group.
Analgesics and antipyretics. Acetylsalicylic acid, combinations without psycholeptics.
Pharmacological properties.
Pharmacodynamics.
Farmadol® is a combined drug with anti-inflammatory, antipyretic and analgesic effects. The action of the drug is determined by its components.
The antipyretic effect of acetylsalicylic acid is realized through the central nervous system by inhibiting the synthesis of prostaglandin PGE2 in the hypothalamus in response to the action of endogenous pyrogens. Its analgesic effectiveness has both a peripheral (inhibition of prostaglandin synthesis in the center of inflammation, prevention of sensitization of pain receptors to mechanical and chemical stimuli) and a central (action on the centers of the hypothalamus, without suppressing consciousness through a hypnotic effect or lowering the mental threshold of pain) origin.
The pain-relieving and antipyretic effect of paracetamol is due to inhibition of prostaglandin synthesis and a predominant effect on the center of thermoregulation in the hypothalamus. It is a much weaker inhibitor of the peripheral biosynthesis system of prostaglandins, which play an important role in the development of the inflammatory reaction.
The mechanism of action of caffeine is due to the inhibition of phosphodiesterase activity, which leads to the accumulation of cAMP. An important link in the mechanism of action of caffeine is its interaction with purine receptors in the brain. It enhances the analgesic effect of acetylsalicylic acid and paracetamol and accelerates its onset.
Pharmacokinetics.
Not researched.
Clinical characteristics.
Indication.
Mild or moderately pronounced pain syndrome (headache, migraine, toothache, neuralgia, arthralgia, primary dysmenorrhea); diseases accompanied by hyperthermic syndrome (as an antipyretic).
Contraindication.
Hypersensitivity to the components of the drug, other xanthine derivatives (theophylline, theobromine), other salicylates; bronchial asthma caused by the use of salicylates or other non-steroidal anti-inflammatory drugs (NSAIDs) in the anamnesis; congenital hyperbilirubinemia, congenital deficiency of glucose-6-phosphate dehydrogenase, blood diseases, leukopenia, anemia, thrombosis, thrombophlebitis, acute gastrointestinal ulcers, hemorrhagic diathesis, severe renal failure, severe liver failure, severe cardiovascular diseases, including rhythm disorders, severe atherosclerosis, severe form of ischemic heart disease, severe heart failure, severe arterial hypertension, tendency to vasospasm; acute pancreatitis, prostatic hypertrophy, severe forms of diabetes; states of increased excitement, sleep disorders, epilepsy, hyperthyroidism, glaucoma, alcoholism. The period of use of monoamine oxidase (MAO) inhibitors, as well as the period within 2 weeks after stopping their use, is contraindicated in patients taking tricyclic antidepressants or beta-blockers. Combination with methotrexate at a dosage of 15 mg/week or more.
Method of application and dosage.
For adults, use Farmadol® 1-2 tablets 2-3 times a day after meals, drink plenty of liquid. The highest daily dose is 6 tablets in 3 doses.
The drug should not be taken for more than 5 days as an analgesic and for more than 3 days – as an antipyretic.
Children. The drug should not be used in children due to the risk of developing Reye’s syndrome (hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche, vomiting, impaired liver function) with hyperthermia against the background of viral diseases.
Expiration date.
2 years.
Do not use the drug after the expiration date indicated on the package.
Storage conditions.
Store in a place protected from light at a temperature not higher than 25 °C. Keep out of the reach of children.
Packaging. 10 tablets in a blister. 1 or 3 or 5 blisters in a pack
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