Storage:
active ingredient: solution of menthol in menthyl ether of isovaleric acid;
1 capsule contains a solution of menthol in menthyl ether of isovaleric acid 100 mg;
excipients: gelatin, glycerin.
Medicinal form. Capsules are soft.
Main physico-chemical properties: soft gelatin capsules of spherical or spherical shape, with a seam, colorless or from weak yellow color to light brownish-yellow color, filled with transparent colorless or yellowish tinged oily liquid with the smell of menthol.
Pharmacotherapeutic group. Cardiac drugs. ATX code C01E X.
Pharmacological properties.
Pharmacodynamics.
The drug has a calming effect on the central nervous system, and also has a moderate reflex vasodilator (coronarolytic) effect by reflex irritation of sensitive nerve (“cold”) receptors of the mucous membrane of the oral cavity. Stimulation of receptors is accompanied by the induction of the release of endorphins, enkephalins, dynorphins and other peptides, histamine, kinins, which play an important role in reducing pain sensitivity, normalizing vascular permeability and regulating other important mechanisms of the functioning of the cardiovascular and nervous systems.
Pharmacokinetics.
When used sublingually, Corvalment® is absorbed from the mucous membrane of the oral cavity. The therapeutic effect occurs after about 5 minutes.
After absorption, it is biotransformed in the liver and removed with urine in the form of glucuronides.
Clinical characteristics.
Indication.
– Mild angina pectoris attacks;
– sea and air diseases;
– hysteria;
– neurosis;
– headache associated with taking nitrates.
Contraindication.
Increased sensitivity to the components of the drug.
Pronounced arterial hypotension; acute myocardial infarction.
Interaction with other medicinal products and other types of interactions.
Corvalment® enhances the sedative effect of psychotropic drugs, opioid analgesics, alcohol and anesthetics when they are used simultaneously.
It is possible to potentiate the action of antihypertensive drugs when they are used simultaneously with the drug Corvalment®.
Corvalment® reduces the severity of headache caused by the use of nitrates.
Features of application.
In cases where pain in the area of the heart does not go away after using the drug, it is necessary to consult a doctor to rule out acute coronary syndrome.
The drug does not contain sugar and can be used by patients with diabetes.
Use during pregnancy or breastfeeding.
The use of the drug during pregnancy or breastfeeding is possible if, in the opinion of the doctor, the expected positive effect for the mother exceeds the potential risk for the fetus/child.
The ability to influence the speed of reaction when driving vehicles or other mechanisms.
Caution is necessary in the first hours after using the drug when driving vehicles or doing work that requires increased attention, due to possible side effects (dizziness and drowsiness).
Method of application and dosage.
Keep the capsule in the mouth (under the tongue) until it is completely dissolved. To accelerate the effect, you can crush the capsule with your teeth.
Single dose for adults – 1 capsule (100 mg).
The maximum daily dose is 6 capsules (600 mg).
Duration of treatment – up to 7 days.
Children.
There is no experience of using the medicinal product for the treatment of children.
Overdose.
Symptoms: headache, nausea, agitation, heart failure, lowering blood pressure, depression of the central nervous system, hypersensitivity reactions to the components of the drug (angioedema, urticaria, itching, rash).
Treatment: withdrawal of the drug and symptomatic therapy.
Adverse reactions.
With long-term use, mild nausea, abdominal discomfort, lacrimation, dizziness, short-term arterial hypotension, drowsiness may occur, which quickly pass on their own.
The development of allergic reactions is possible, including angioedema, urticaria, rashes, itching.
Expiration date. 3 years.
Storage conditions.
Store in the original packaging at a temperature not higher than 25 oC.
Keep out of the reach of children.
Packaging.
10 capsules in blisters.
10 capsules in a blister; 3 blisters in a pack.
20 capsules in a blister; 1 blister in a pack.
20 capsules in a blister; 3 blisters in a pack.
20 capsules in a blister; 4 blisters in a pack.
Leave category. Without a prescription.
Producer. JSC “KYIV VITAMINY ZAVOD”.
The location of the manufacturer and the address of the place of its activity.
04073, Ukraine, Kyiv, st. Kopylivska, 38.
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